insulin resistance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. (Human Phenotype Ontology, HP_0000855)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005331
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Genes

114 gene mutations causing the insulin resistance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
ALX3 ALX homeobox 3
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
APOC3 apolipoprotein C-III
ASIP agouti signaling protein
BGLAP bone gamma-carboxyglutamate (gla) protein
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CAV1 caveolin 1, caveolae protein, 22kDa
CD38 CD38 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP19 centrosomal protein 19kDa
CLOCK clock circadian regulator
COL5A3 collagen, type V, alpha 3
CORT cortistatin
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CSPG4 chondroitin sulfate proteoglycan 4
CTF1 cardiotrophin 1
CTHRC1 collagen triple helix repeat containing 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDIT3 DNA-damage-inducible transcript 3
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FFAR4 free fatty acid receptor 4
FOXO1 forkhead box O1
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GRM8 glutamate receptor, metabotropic 8
GYS2 glycogen synthase 2 (liver)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HMGA1 high mobility group AT-hook 1
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL1R1 interleukin 1 receptor, type I
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KMT2B lysine (K)-specific methyltransferase 2B
LCMT1 leucine carboxyl methyltransferase 1
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LNPEP leucyl/cystinyl aminopeptidase
LPIN1 lipin 1
LRP5 low density lipoprotein receptor-related protein 5
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MLXIPL MLX interacting protein-like
MSTN myostatin
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NCOR2 nuclear receptor corepressor 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
OSMR oncostatin M receptor
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLSCR3 phospholipid scramblase 3
PNLIP pancreatic lipase
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PTRF polymerase I and transcript release factor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SESN2 sestrin 2
SH2B1 SH2B adaptor protein 1
SIM1 single-minded family bHLH transcription factor 1
SIRT3 sirtuin 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SOCS2 suppressor of cytokine signaling 2
STEAP4 STEAP family member 4
STX4 syntaxin 4
STXBP3 syntaxin binding protein 3
TBC1D4 TBC1 domain family, member 4
TERF2IP telomeric repeat binding factor 2, interacting protein
THRA thyroid hormone receptor, alpha
TLR5 toll-like receptor 5
TRIB1 tribbles pseudokinase 1
WDTC1 WD and tetratricopeptide repeats 1
WRN Werner syndrome, RecQ helicase-like
ZEB1 zinc finger E-box binding homeobox 1