insulin resistance Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. (Human Phenotype Ontology, HP_0000855)
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Genes

117 genes associated with the disease insulin resistance in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACBD6 acyl-CoA binding domain containing 6
ACE angiotensin I converting enzyme
ADAM10 ADAM metallopeptidase domain 10
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
ALK anaplastic lymphoma receptor tyrosine kinase
ANK1 ankyrin 1, erythrocytic
ANK2 ankyrin 2, neuronal
APOB apolipoprotein B
APOC3 apolipoprotein C-III
AR androgen receptor
ASB7 ankyrin repeat and SOCS box containing 7
ASIC3 acid sensing (proton gated) ion channel 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BFSP2 beaded filament structural protein 2, phakinin
C1ORF131 chromosome 1 open reading frame 131
C9ORF3 chromosome 9 open reading frame 3
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAPN9 calpain 9
CAPZB capping protein (actin filament) muscle Z-line, beta
CCDC88A coiled-coil domain containing 88A
CCDC88C coiled-coil domain containing 88C
CERS6 ceramide synthase 6
CKS2 CDC28 protein kinase regulatory subunit 2
CSMD1 CUB and Sushi multiple domains 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
DIO2 deiodinase, iodothyronine, type II
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHB2 EPH receptor B2
F9 coagulation factor IX
FABP2 fatty acid binding protein 2, intestinal
FAM129A family with sequence similarity 129, member A
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
FAM63B family with sequence similarity 63, member B
FBXL17 F-box and leucine-rich repeat protein 17
FOXC2 forkhead box C2
FOXO3 forkhead box O3
FSTL4 follistatin-like 4
FTO fat mass and obesity associated
FYN FYN proto-oncogene, Src family tyrosine kinase
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHRL ghrelin/obestatin prepropeptide
GPA33 glycoprotein A33 (transmembrane)
GYS1 glycogen synthase 1 (muscle)
HELZ helicase with zinc finger
HFE hemochromatosis
HHLA2 HERV-H LTR-associating 2
HMGA2 high mobility group AT-hook 2
HNF1A HNF1 homeobox A
HOMER3 homer scaffolding protein 3
HYOU1 hypoxia up-regulated 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKZF2 IKAROS family zinc finger 2 (Helios)
IL6 interleukin 6
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK2 Janus kinase 2
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KLF11 Kruppel-like factor 11
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LPL lipoprotein lipase
LRRC4C leucine rich repeat containing 4C
LRRTM4 leucine rich repeat transmembrane neuronal 4
MBOAT1 membrane bound O-acyltransferase domain containing 1
MC4R melanocortin 4 receptor
MTNR1B melatonin receptor 1B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5DC1 5'-nucleotidase domain containing 1
OGG1 8-oxoguanine DNA glycosylase
PARK2 parkin RBR E3 ubiquitin protein ligase
PCDH9 protocadherin 9
PFKP phosphofructokinase, platelet
PITRM1 pitrilysin metallopeptidase 1
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PTK2B protein tyrosine kinase 2 beta
RETN resistin
SCAI suppressor of cancer cell invasion
SEZ6L seizure related 6 homolog (mouse)-like
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SRPK2 SRSF protein kinase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TH tyrosine hydroxylase
TNF tumor necrosis factor
TNRC6B trinucleotide repeat containing 6B
TRIB3 tribbles pseudokinase 3
TRRAP transformation/transcription domain-associated protein
TSSC1 tumor suppressing subtransferable candidate 1
UBE2N ubiquitin-conjugating enzyme E2N
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UNC5C unc-5 homolog C (C. elegans)
VWA8 von Willebrand factor A domain containing 8
ZFAND3 zinc finger, AN1-type domain 3
ZNF286B zinc finger protein 286B
ZP4 zona pellucida glycoprotein 4