indoprofen-4249 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the indoprofen-4249 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ACTN2 actinin, alpha 2
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ATXN7L1 ataxin 7-like 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C9ORF16 chromosome 9 open reading frame 16
CCDC7 coiled-coil domain containing 7
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLIC5 chloride intracellular channel 5
COL4A6 collagen, type IV, alpha 6
DCTN2 dynactin 2 (p50)
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPF1 D4, zinc and double PHD fingers family 1
DTNA dystrobrevin, alpha
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EPHB1 EPH receptor B1
EPS8L1 EPS8-like 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
FAM76A family with sequence similarity 76, member A
FGL2 fibrinogen-like 2
FLOT1 flotillin 1
FOXN3 forkhead box N3
GAS7 growth arrest-specific 7
GJA9 gap junction protein, alpha 9, 59kDa
GJD2 gap junction protein, delta 2, 36kDa
GLB1L galactosidase, beta 1-like
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPATCH4 G patch domain containing 4
GTDC1 glycosyltransferase-like domain containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HEG1 heart development protein with EGF-like domains 1
HOPX HOP homeobox
HOXB7 homeobox B7
ICAM1 intercellular adhesion molecule 1
IGHM immunoglobulin heavy constant mu
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL21R interleukin 21 receptor
INE1 inactivation escape 1 (non-protein coding)
ITGA7 integrin, alpha 7
ITPK1 inositol-tetrakisphosphate 1-kinase
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KANK1 KN motif and ankyrin repeat domains 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK11 mitogen-activated protein kinase 11
MBD2 methyl-CpG binding domain protein 2
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
N4BP2L1 NEDD4 binding protein 2-like 1
NEU3 sialidase 3 (membrane sialidase)
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NUMA1 nuclear mitotic apparatus protein 1
OAZ3 ornithine decarboxylase antizyme 3
PADI1 peptidyl arginine deiminase, type I
PALMD palmdelphin
PCDH17 protocadherin 17
PCSK6 proprotein convertase subtilisin/kexin type 6
PHOX2B paired-like homeobox 2b
PKNOX1 PBX/knotted 1 homeobox 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PTK2B protein tyrosine kinase 2 beta
RANBP1 RAN binding protein 1
RB1 retinoblastoma 1
RGS5 regulator of G-protein signaling 5
ROM1 retinal outer segment membrane protein 1
RPS14 ribosomal protein S14
RUNX1 runt-related transcription factor 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SIT1 signaling threshold regulating transmembrane adaptor 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD4 SMAD family member 4
SOCS3 suppressor of cytokine signaling 3
SOX15 SRY (sex determining region Y)-box 15
SPON1 spondin 1, extracellular matrix protein
SPPL2B signal peptide peptidase like 2B
SUGP1 SURP and G patch domain containing 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TMOD1 tropomodulin 1
TTC39A tetratricopeptide repeat domain 39A
USP9Y ubiquitin specific peptidase 9, Y-linked
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZBTB7A zinc finger and BTB domain containing 7A
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF225 zinc finger protein 225
ZNF24 zinc finger protein 24
ZNF334 zinc finger protein 334
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ADGRB2 adhesion G protein-coupled receptor B2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX12 arachidonate 12-lipoxygenase
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BFSP1 beaded filament structural protein 1, filensin
C1R complement component 1, r subcomponent
C22ORF46 chromosome 22 open reading frame 46
C5ORF42 chromosome 5 open reading frame 42
CA9 carbonic anhydrase IX
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CEP295 centrosomal protein 295kDa
CFAP45 cilia and flagella associated protein 45
CGREF1 cell growth regulator with EF-hand domain 1
CLDN1 claudin 1
CLEC2B C-type lectin domain family 2, member B
CLIP2 CAP-GLY domain containing linker protein 2
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CXCR2 chemokine (C-X-C motif) receptor 2
CXORF21 chromosome X open reading frame 21
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DSPP dentin sialophosphoprotein
EDN1 endothelin 1
EFHD2 EF-hand domain family, member D2
FAM120C family with sequence similarity 120C
FAM127A family with sequence similarity 127, member A
FOXD1 forkhead box D1
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAS8 growth arrest-specific 8
GMIP GEM interacting protein
GPR75 G protein-coupled receptor 75
GRM4 glutamate receptor, metabotropic 4
HIST1H1D histone cluster 1, H1d
HIST1H3A histone cluster 1, H3a
HOXA4 homeobox A4
HSPB6 heat shock protein, alpha-crystallin-related, B6
IL12RB1 interleukin 12 receptor, beta 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KRT34 keratin 34, type I
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRP3 low density lipoprotein receptor-related protein 3
LRRC61 leucine rich repeat containing 61
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MAGEA6 melanoma antigen family A6
MATN3 matrilin 3
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFGE8 milk fat globule-EGF factor 8 protein
MMP13 matrix metallopeptidase 13
MVP major vault protein
MXRA8 matrix-remodelling associated 8
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
OSBP2 oxysterol binding protein 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLL polymerase (DNA directed), lambda
PRM2 protamine 2
PRR7 proline rich 7 (synaptic)
PTK6 protein tyrosine kinase 6
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SCEL sciellin
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SH2D2A SH2 domain containing 2A
SLC16A6 solute carrier family 16, member 6
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOX12 SRY (sex determining region Y)-box 12
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STRN4 striatin, calmodulin binding protein 4
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TLN1 talin 1
TOM1 target of myb1 (chicken)
TUBB2B tubulin, beta 2B class IIb
USP27X ubiquitin specific peptidase 27, X-linked
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNT1 wingless-type MMTV integration site family, member 1
XAB2 XPA binding protein 2
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF442 zinc finger protein 442
ZNF749 zinc finger protein 749