indometacin-262 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the indometacin-262 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAP1 ArfGAP with dual PH domains 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARFRP1 ADP-ribosylation factor related protein 1
ARHGAP19 Rho GTPase activating protein 19
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATM ATM serine/threonine kinase
ATXN2L ataxin 2-like
BCAM basal cell adhesion molecule (Lutheran blood group)
CASKIN2 CASK interacting protein 2
CBX2 chromobox homolog 2
CCNK cyclin K
CHERP calcium homeostasis endoplasmic reticulum protein
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CSF1R colony stimulating factor 1 receptor
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CXCR4 chemokine (C-X-C motif) receptor 4
DCAF8 DDB1 and CUL4 associated factor 8
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIO2 deiodinase, iodothyronine, type II
DMWD dystrophia myotonica, WD repeat containing
DST dystonin
DTX3 deltex 3, E3 ubiquitin ligase
EFNB3 ephrin-B3
EHD1 EH-domain containing 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
ENG endoglin
EPN1 epsin 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FAXDC2 fatty acid hydroxylase domain containing 2
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FNDC3A fibronectin type III domain containing 3A
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HLF hepatic leukemia factor
HMP19 HMP19 protein
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL12RB1 interleukin 12 receptor, beta 1
IL15RA interleukin 15 receptor, alpha
IRF8 interferon regulatory factor 8
KDM5D lysine (K)-specific demethylase 5D
KHSRP KH-type splicing regulatory protein
KLHL22 kelch-like family member 22
L1CAM L1 cell adhesion molecule
LPPR2 lipid phosphate phosphatase-related protein type 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MED1 mediator complex subunit 1
MED18 mediator complex subunit 18
MEFV Mediterranean fever
MEGF9 multiple EGF-like-domains 9
MYO1F myosin IF
NNAT neuronatin
NOX1 NADPH oxidase 1
PACS1 phosphofurin acidic cluster sorting protein 1
PAX3 paired box 3
PCDHB6 protocadherin beta 6
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNB3 plexin B3
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRG3 proteoglycan 3
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PXN paxillin
RCVRN recoverin
RPLP2 ribosomal protein, large, P2
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SIGLEC5 sialic acid binding Ig-like lectin 5
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SOX21 SRY (sex determining region Y)-box 21
SPIN2A spindlin family, member 2A
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
T T, brachyury homolog (mouse)
TAOK2 TAO kinase 2
TEK TEK tyrosine kinase, endothelial
TLN2 talin 2
TMEM143 transmembrane protein 143
TMEM176A transmembrane protein 176A
TMF1 TATA element modulatory factor 1
TNK1 tyrosine kinase, non-receptor, 1
TP53I11 tumor protein p53 inducible protein 11
USP20 ubiquitin specific peptidase 20
VRK3 vaccinia related kinase 3
YIPF6 Yip1 domain family, member 6
YY1 YY1 transcription factor
ZNF460 zinc finger protein 460

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
AHSG alpha-2-HS-glycoprotein
ANGPT4 angiopoietin 4
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
BACE1 beta-site APP-cleaving enzyme 1
BAGE B melanoma antigen
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF109 chromosome 1 open reading frame 109
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CBLN1 cerebellin 1 precursor
CD180 CD180 molecule
CD19 CD19 molecule
CD27 CD27 molecule
CDH22 cadherin 22, type 2
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CNGA1 cyclic nucleotide gated channel alpha 1
CP ceruloplasmin (ferroxidase)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGAT1 diacylglycerol O-acyltransferase 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DYSF dysferlin
ECE2 endothelin converting enzyme 2
FBLN5 fibulin 5
FGL1 fibrinogen-like 1
FGR FGR proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1
GDF5 growth differentiation factor 5
GLRA2 glycine receptor, alpha 2
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AM histone cluster 1, H2am
ICK intestinal cell (MAK-like) kinase
IFNA5 interferon, alpha 5
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL13 interleukin 13
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KIAA1324 KIAA1324
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHDC8A kelch domain containing 8A
KLHL3 kelch-like family member 3
KRI1 KRI1 homolog (S. cerevisiae)
KRT75 keratin 75, type II
LGALS13 lectin, galactoside-binding, soluble, 13
LUZP2 leucine zipper protein 2
MAGEA5 melanoma antigen family A5
MATK megakaryocyte-associated tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MUC2 mucin 2, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYL1 myosin, light chain 1, alkali; skeletal, fast
NPPB natriuretic peptide B
OPRD1 opioid receptor, delta 1
OR5I1 olfactory receptor, family 5, subfamily I, member 1
OSGIN1 oxidative stress induced growth inhibitor 1
PNMT phenylethanolamine N-methyltransferase
POGLUT1 protein O-glucosyltransferase 1
PPARG peroxisome proliferator-activated receptor gamma
PRDM1 PR domain containing 1, with ZNF domain
PSG11 pregnancy specific beta-1-glycoprotein 11
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASL11B RAS-like, family 11, member B
RIMBP2 RIMS binding protein 2
RNF141 ring finger protein 141
RPL10L ribosomal protein L10-like
RPL23AP7 ribosomal protein L23a pseudogene 7
SCGN secretagogin, EF-hand calcium binding protein
SCUBE3 signal peptide, CUB domain, EGF-like 3
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIL1 SIL1 nucleotide exchange factor
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPRR3 small proline-rich protein 3
STAG3 stromal antigen 3
STK17B serine/threonine kinase 17b
SYNPO synaptopodin
TMEM165 transmembrane protein 165
TMEM254 transmembrane protein 254
TNRC6B trinucleotide repeat containing 6B
TRAC T cell receptor alpha constant
TRPV5 transient receptor potential cation channel, subfamily V, member 5
WNT2 wingless-type MMTV integration site family member 2
WNT3 wingless-type MMTV integration site family, member 3
XYLT2 xylosyltransferase II
ZCCHC10 zinc finger, CCHC domain containing 10
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZNF134 zinc finger protein 134
ZNF180 zinc finger protein 180
ZNF639 zinc finger protein 639