increased triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver (Mammalian Phenotype Ontology, MP_0005317)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005317
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Genes

174 gene mutations causing the increased triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABHD5 abhydrolase domain containing 5
ACACB acetyl-CoA carboxylase beta
ACOT11 acyl-CoA thioesterase 11
ADCY10 adenylate cyclase 10 (soluble)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRG6 adhesion G protein-coupled receptor G6
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALMS1 Alstrom syndrome protein 1
ALPI alkaline phosphatase, intestinal
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP8 aquaporin 8
AQP9 aquaporin 9
BCO2 beta-carotene oxygenase 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BHMT betaine--homocysteine S-methyltransferase
BRD2 bromodomain containing 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP19 centrosomal protein 19kDa
CHKA choline kinase alpha
CLOCK clock circadian regulator
COL18A1 collagen, type XVIII, alpha 1
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
ECI1 enoyl-CoA delta isomerase 1
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERCC1 excision repair cross-complementation group 1
FABP3 fatty acid binding protein 3, muscle and heart
FADS2 fatty acid desaturase 2
FFAR1 free fatty acid receptor 1
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FOXA2 forkhead box A2
FTO fat mass and obesity associated
G6PC glucose-6-phosphatase, catalytic subunit
GALR3 galanin receptor 3
GCK glucokinase (hexokinase 4)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GPR12 G protein-coupled receptor 12
GPR26 G protein-coupled receptor 26
GPRC6A G protein-coupled receptor, class C, group 6, member A
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HADH hydroxyacyl-CoA dehydrogenase
HRH1 histamine receptor H1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IL10 interleukin 10
IL21R interleukin 21 receptor
IL25 interleukin 25
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KDM3A lysine (K)-specific demethylase 3A
KMT2B lysine (K)-specific methyltransferase 2B
LAMB2 laminin, beta 2 (laminin S)
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEP leptin
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LIPG lipase, endothelial
LIPI lipase, member I
LMF1 lipase maturation factor 1
LMNA lamin A/C
LPIN1 lipin 1
LPL lipoprotein lipase
LYPD3 LY6/PLAUR domain containing 3
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR122 microRNA 122
MIR378A microRNA 378a
MTTP microsomal triglyceride transfer protein
MUC2 mucin 2, oligomeric mucus/gel-forming
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NMU neuromedin U
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUAK2 NUAK family, SNF1-like kinase, 2
OCA2 oculocutaneous albinism II
OMA1 OMA1 zinc metallopeptidase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSBPL8 oxysterol binding protein-like 8
OSMR oncostatin M receptor
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE3B phosphodiesterase 3B, cGMP-inhibited
PEX11A peroxisomal biogenesis factor 11 alpha
PLAGL2 pleiomorphic adenoma gene-like 2
PLIN5 perilipin 5
PLSCR3 phospholipid scramblase 3
PLVAP plasmalemma vesicle associated protein
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRF1 perforin 1 (pore forming protein)
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PROX1 prospero homeobox 1
PTRF polymerase I and transcript release factor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RGN regucalcin
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSBN1 round spermatid basic protein 1
SCARB1 scavenger receptor class B, member 1
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SESN2 sestrin 2
SIK3 SIK family kinase 3
SIRT3 sirtuin 3
SIRT7 sirtuin 7
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOAT2 sterol O-acyltransferase 2
SOCS2 suppressor of cytokine signaling 2
STEAP4 STEAP family member 4
TLR5 toll-like receptor 5
TRA2B transformer 2 beta homolog (Drosophila)
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TUB tubby bipartite transcription factor
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
VLDLR very low density lipoprotein receptor
WRN Werner syndrome, RecQ helicase-like
XDH xanthine dehydrogenase
ZEB1 zinc finger E-box binding homeobox 1