increased t cell proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli (Mammalian Phenotype Ontology, MP_0005348)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005348
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Genes

100 gene mutations causing the increased t cell proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTLA B and T lymphocyte associated
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCR6 chemokine (C-C motif) receptor 6
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD5 CD5 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CISH cytokine inducible SH2-containing protein
CRTAM cytotoxic and regulatory T cell molecule
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DCK deoxycytidine kinase
DGKZ diacylglycerol kinase, zeta
DTX1 deltex 1, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELF4 E74-like factor 4 (ets domain transcription factor)
FASLG Fas ligand (TNF superfamily, member 6)
FOXO3 forkhead box O3
FOXP3 forkhead box P3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR132 G protein-coupled receptor 132
GRAP GRB2-related adaptor protein
HSH2D hematopoietic SH2 domain containing
IFNB1 interferon, beta 1, fibroblast
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL12B interleukin 12B
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL2 interleukin 2
IL20RB interleukin 20 receptor beta
IL27RA interleukin 27 receptor, alpha
IL31RA interleukin 31 receptor A
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
JUND jun D proto-oncogene
LAPTM5 lysosomal protein transmembrane 5
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK8 mitogen-activated protein kinase 8
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MBP myelin basic protein
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
MTA2 metastasis associated 1 family, member 2
MXI1 MAX interactor 1, dimerization protein
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NUP98 nucleoporin 98kDa
PAWR PRKC, apoptosis, WT1, regulator
PGAP3 post-GPI attachment to proteins 3
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RHOH ras homolog family member H
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAC3D1 SAC3 domain containing 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SELL selectin L
SH2D1A SH2 domain containing 1A
SIT1 signaling threshold regulating transmembrane adaptor 1
SOX13 SRY (sex determining region Y)-box 13
SPN sialophorin
SPTA1 spectrin, alpha, erythrocytic 1
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
TBC1D10C TBC1 domain family, member 10C
TESPA1 thymocyte expressed, positive selection associated 1
THEMIS thymocyte selection associated
TIGIT T cell immunoreceptor with Ig and ITIM domains
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAF1 TNF receptor-associated factor 1
TSPAN32 tetraspanin 32
TXNIP thioredoxin interacting protein
ZBTB32 zinc finger and BTB domain containing 32
ZC3H12D zinc finger CCCH-type containing 12D