increased systemic arterial systolic blood pressure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries (Mammalian Phenotype Ontology, MP_0006144)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006144
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Genes

58 gene mutations causing the increased systemic arterial systolic blood pressure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE2 angiotensin I converting enzyme 2
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2B adenosine A2b receptor
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGTRAP angiotensin II receptor-associated protein
ASL argininosuccinate lyase
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CD47 CD47 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL3A1 collagen, type III, alpha 1
CORIN corin, serine peptidase
CTSA cathepsin A
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DLL1 delta-like 1 (Drosophila)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD5 dopamine receptor D5
ELN elastin
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSTL3 follistatin-like 3 (secreted glycoprotein)
GSE1 Gse1 coiled-coil protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HRAS Harvey rat sarcoma viral oncogene homolog
IDUA iduronidase, alpha-L-
IGF1 insulin-like growth factor 1 (somatomedin C)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRAS Kirsten rat sarcoma viral oncogene homolog
NCALD neurocalcin delta
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR1 natriuretic peptide receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDC phosducin
POMC proopiomelanocortin
PRKG1 protein kinase, cGMP-dependent, type I
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RNLS renalase, FAD-dependent amine oxidase
SCNN1B sodium channel, non voltage gated 1 beta subunit
SIRT3 sirtuin 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18
SOX13 SRY (sex determining region Y)-box 13
TGFB1 transforming growth factor, beta 1
TLR5 toll-like receptor 5
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1