increased systemic arterial diastolic blood pressure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed (Mammalian Phenotype Ontology, MP_0006143)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006143
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Genes

35 gene mutations causing the increased systemic arterial diastolic blood pressure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ADD2 adducin 2 (beta)
AGTR2 angiotensin II receptor, type 2
ASL argininosuccinate lyase
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CD47 CD47 molecule
CTSA cathepsin A
DLL1 delta-like 1 (Drosophila)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD5 dopamine receptor D5
ELN elastin
FKBP1B FK506 binding protein 1B, 12.6 kDa
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IRS1 insulin receptor substrate 1
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRK2 leucine-rich repeat kinase 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
PDC phosducin
PRKG1 protein kinase, cGMP-dependent, type I
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNLS renalase, FAD-dependent amine oxidase
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
THBS1 thrombospondin 1
TLR5 toll-like receptor 5
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNK1 WNK lysine deficient protein kinase 1
ZRANB2 zinc finger, RAN-binding domain containing 2