increased systemic arterial blood pressure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased tension of the blood within the systemic arteries (Mammalian Phenotype Ontology, MP_0002842)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002842
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Genes

122 gene mutations causing the increased systemic arterial blood pressure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGTRAP angiotensin II receptor-associated protein
AGXT2 alanine--glyoxylate aminotransferase 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARL6 ADP-ribosylation factor-like 6
ASL argininosuccinate lyase
BRS3 bombesin-like receptor 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CALCB calcitonin-related polypeptide beta
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGA chromogranin A
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CORIN corin, serine peptidase
CRHR2 corticotropin releasing hormone receptor 2
CTH cystathionine gamma-lyase
CTSA cathepsin A
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DDAH1 dimethylarginine dimethylaminohydrolase 1
DLL1 delta-like 1 (Drosophila)
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD5 dopamine receptor D5
EDN1 endothelin 1
EDNRB endothelin receptor type B
ELN elastin
ESR2 estrogen receptor 2 (ER beta)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GDNF glial cell derived neurotrophic factor
GPER1 G protein-coupled estrogen receptor 1
GSE1 Gse1 coiled-coil protein
GUCA2B guanylate cyclase activator 2B (uroguanylin)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IDUA iduronidase, alpha-L-
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRAS Kirsten rat sarcoma viral oncogene homolog
LEPR leptin receptor
LRRK2 leucine-rich repeat kinase 2
MKKS McKusick-Kaufman syndrome
MPV17 MpV17 mitochondrial inner membrane protein
NCALD neurocalcin delta
NCF1 neutrophil cytosolic factor 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCSK2 proprotein convertase subtilisin/kexin type 2
PDC phosducin
PNMT phenylethanolamine N-methyltransferase
PODXL podocalyxin-like
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PRKG1 protein kinase, cGMP-dependent, type I
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RGS2 regulator of G-protein signaling 2
RNLS renalase, FAD-dependent amine oxidase
SCNN1B sodium channel, non voltage gated 1 beta subunit
SIRT3 sirtuin 3
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18
SMAD6 SMAD family member 6
SMTN smoothelin
SOX13 SRY (sex determining region Y)-box 13
TAL1 T-cell acute lymphocytic leukemia 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TLR5 toll-like receptor 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNK1 WNK lysine deficient protein kinase 1
WNK4 WNK lysine deficient protein kinase 4
XBP1 X-box binding protein 1
ZRANB2 zinc finger, RAN-binding domain containing 2