increased susceptibility to systemic lupus erythematosus Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs (Mammalian Phenotype Ontology, MP_0004801)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004801
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Genes

14 gene mutations causing the increased susceptibility to systemic lupus erythematosus phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
CORO1A coronin, actin binding protein, 1A
DNASE1 deoxyribonuclease I
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
LYN LYN proto-oncogene, Src family tyrosine kinase
MTA2 metastasis associated 1 family, member 2
MTUS1 microtubule associated tumor suppressor 1
POLB polymerase (DNA directed), beta
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SCARF1 scavenger receptor class F, member 1
TBC1D10C TBC1 domain family, member 10C
TNIP1 TNFAIP3 interacting protein 1
TREX1 three prime repair exonuclease 1