increased susceptibility to ototoxicity-induced hearing loss Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process (Mammalian Phenotype Ontology, MP_0004611)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004611
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Genes

2 gene mutations causing the increased susceptibility to ototoxicity-induced hearing loss phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3