increased susceptibility to neuronal excitotoxicity Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process (Mammalian Phenotype Ontology, MP_0008235)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008235
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Genes

28 gene mutations causing the increased susceptibility to neuronal excitotoxicity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AKT3 v-akt murine thymoma viral oncogene homolog 3
CAST calpastatin
CNR1 cannabinoid receptor 1 (brain)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DRD2 dopamine receptor D2
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRN granulin
HPCA hippocalcin
HTRA2 HtrA serine peptidase 2
HYOU1 hypoxia up-regulated 1
IL10 interleukin 10
IL6 interleukin 6
LYNX1 Ly6/neurotoxin 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS4 neuronal PAS domain protein 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGG1 8-oxoguanine DNA glycosylase
PARK7 parkinson protein 7
PSEN1 presenilin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)