increased susceptibility to injury Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the normal reaction to trauma, especially that by physical means (Mammalian Phenotype Ontology, MP_0005165)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005165
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Genes

102 gene mutations causing the increased susceptibility to injury phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABRA actin binding Rho activating protein
AHR aryl hydrocarbon receptor
APLN apelin
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BIRC5 baculoviral IAP repeat containing 5
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAPN8 calpain 8
CAPN9 calpain 9
CASQ2 calsequestrin 2 (cardiac muscle)
CAV1 caveolin 1, caveolae protein, 22kDa
CD19 CD19 molecule
CD1D CD1d molecule
CD274 CD274 molecule
CD2AP CD2-associated protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGN cingulin
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COL13A1 collagen, type XIII, alpha 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CST3 cystatin C
CYR61 cysteine-rich, angiogenic inducer, 61
DACT3 dishevelled-binding antagonist of beta-catenin 3
DCR Down syndrome chromosome region
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAIM2 Fas apoptotic inhibitory molecule 2
FAM132B family with sequence similarity 132, member B
FLT1 fms-related tyrosine kinase 1
GFAP glial fibrillary acidic protein
GJA5 gap junction protein, alpha 5, 40kDa
GLRX3 glutaredoxin 3
GPR22 G protein-coupled receptor 22
GPX1 glutathione peroxidase 1
GRM1 glutamate receptor, metabotropic 1
GRN granulin
GSN gelsolin
HRC histidine rich calcium binding protein
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IL10 interleukin 10
IL27RA interleukin 27 receptor, alpha
INPP5F inositol polyphosphate-5-phosphatase F
ITGA1 integrin, alpha 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDR kinase insert domain receptor
KLF15 Kruppel-like factor 15
KLHL20 kelch-like family member 20
LDB3 LIM domain binding 3
LITAF lipopolysaccharide-induced TNF factor
LTA lymphotoxin alpha
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK8 mitogen-activated protein kinase 8
MGMT O-6-methylguanine-DNA methyltransferase
MIR22 microRNA 22
MYBPC3 myosin binding protein C, cardiac
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK3 myosin light chain kinase 3
MYOZ2 myozenin 2
NDRG4 NDRG family member 4
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK6 NIMA-related kinase 6
NFE2L2 nuclear factor, erythroid 2-like 2
NOTCH3 notch 3
NOX4 NADPH oxidase 4
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCE1 phospholipase C, epsilon 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PSPN persephin
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RDH13 retinol dehydrogenase 13 (all-trans/9-cis)
REG1B regenerating islet-derived 1 beta
RYR2 ryanodine receptor 2 (cardiac)
SFTPB surfactant protein B
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SOCS1 suppressor of cytokine signaling 1
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
SSPN sarcospan
STIP1 stress-induced phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCAP titin-cap
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNF tumor necrosis factor
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UNG uracil-DNA glycosylase