increased susceptibility to induction of seizure by inducing agent Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description lower threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior (Mammalian Phenotype Ontology, MP_0012349)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012349
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Genes

83 gene mutations causing the increased susceptibility to induction of seizure by inducing agent phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMPH amphiphysin
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARX aristaless related homeobox
AVPR1B arginine vasopressin receptor 1B
BHLHE40 basic helix-loop-helix family, member e40
BSN bassoon presynaptic cytomatrix protein
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIT citron rho-interacting serine/threonine kinase
CLN3 ceroid-lipofuscinosis, neuronal 3
CNR1 cannabinoid receptor 1 (brain)
CNTN2 contactin 2 (axonal)
DRD2 dopamine receptor D2
EFHC1 EF-hand domain (C-terminal) containing 1
FAIM2 Fas apoptotic inhibitory molecule 2
FGF14 fibroblast growth factor 14
FGF7 fibroblast growth factor 7
FZD9 frizzled class receptor 9
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAL galanin/GMAP prepropeptide
GDI1 GDP dissociation inhibitor 1
GFAP glial fibrillary acidic protein
GLRA1 glycine receptor, alpha 1
GLRA3 glycine receptor, alpha 3
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCRTR1 hypocretin (orexin) receptor 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLK8 kallikrein-related peptidase 8
LGI1 leucine-rich, glioma inactivated 1
LHX6 LIM homeobox 6
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECP2 methyl CpG binding protein 2
MT3 metallothionein 3
NEUROD2 neuronal differentiation 2
NOS2 nitric oxide synthase 2, inducible
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP2 neuropilin 2
OPRD1 opioid receptor, delta 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE8A phosphodiesterase 8A
PDYN prodynorphin
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCL1 phospholipase C-like 1
PRICKLE2 prickle homolog 2 (Drosophila)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RYR2 ryanodine receptor 2 (cardiac)
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC10A4 solute carrier family 10, member 4
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SYNGAP1 synaptic Ras GTPase activating protein 1
SZT2 seizure threshold 2 homolog (mouse)