increased susceptibility to experimental autoimmune encephalomyelitis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG) (Mammalian Phenotype Ontology, MP_0004799)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004799
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Genes

52 gene mutations causing the increased susceptibility to experimental autoimmune encephalomyelitis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
BTLA B and T lymphocyte associated
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD19 CD19 molecule
CD200 CD200 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD300LF CD300 molecule-like family member f
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CNTF ciliary neurotrophic factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
GADD45B growth arrest and DNA-damage-inducible, beta
HCST hematopoietic cell signal transducer
HLA-E major histocompatibility complex, class I, E
HRH3 histamine receptor H3
ICOS inducible T-cell co-stimulator
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL21 interleukin 21
IL21R interleukin 21 receptor
IL25 interleukin 25
IL27 interleukin 27
IL9R interleukin 9 receptor
LGALS1 lectin, galactoside-binding, soluble, 1
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK3 mitogen-activated protein kinase 3
MBP myelin basic protein
MMP2 matrix metallopeptidase 2
MOG myelin oligodendrocyte glycoprotein
MPO myeloperoxidase
MR1 major histocompatibility complex, class I-related
NFIL3 nuclear factor, interleukin 3 regulated
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDCD1 programmed cell death 1
PGAP3 post-GPI attachment to proteins 3
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SIT1 signaling threshold regulating transmembrane adaptor 1
TIGIT T cell immunoreceptor with Ig and ITIM domains
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
USP25 ubiquitin specific peptidase 25
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
ZC3H12D zinc finger CCCH-type containing 12D