increased susceptibility to dopaminergic neuron neurotoxicity Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism (Mammalian Phenotype Ontology, MP_0011451)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011451
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Genes

11 gene mutations causing the increased susceptibility to dopaminergic neuron neurotoxicity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DRD2 dopamine receptor D2
GRN granulin
IL6 interleukin 6
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARK7 parkinson protein 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)