increased susceptibility to autoimmune diabetes Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas (Mammalian Phenotype Ontology, MP_0004803)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004803
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Genes

16 gene mutations causing the increased susceptibility to autoimmune diabetes phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
CD274 CD274 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD86 CD86 molecule
E2F1 E2F transcription factor 1
IGHM immunoglobulin heavy constant mu
IL2 interleukin 2
INS insulin
LEPR leptin receptor
PDCD1LG2 programmed cell death 1 ligand 2
PTPRN protein tyrosine phosphatase, receptor type, N
TLR5 toll-like receptor 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1