increased squamous cell carcinoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal incidence of a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix (Mammalian Phenotype Ontology, MP_0004207)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004207
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Genes

26 gene mutations causing the increased squamous cell carcinoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHUK conserved helix-loop-helix ubiquitous kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
HIC1 hypermethylated in cancer 1
KRAS Kirsten rat sarcoma viral oncogene homolog
MET MET proto-oncogene, receptor tyrosine kinase
MLH1 mutL homolog 1
MSH2 mutS homolog 2
NKX2-8 NK2 homeobox 8
PLK1 polo-like kinase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLH polymerase (DNA directed), eta
RINT1 RAD50 interactor 1
SFN stratifin
SSBP2 single-stranded DNA binding protein 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TRIM62 tripartite motif containing 62
TUSC2 tumor suppressor candidate 2
XPA xeroderma pigmentosum, complementation group A