increased spleen white pulp amount Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies (Mammalian Phenotype Ontology, MP_0008478)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008478
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Genes

21 gene mutations causing the increased spleen white pulp amount phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APCS amyloid P component, serum
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BHLHE40 basic helix-loop-helix family, member e40
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
DIDO1 death inducer-obliterator 1
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LYN LYN proto-oncogene, Src family tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MXI1 MAX interactor 1, dimerization protein
PTPRC protein tyrosine phosphatase, receptor type, C
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STEAP3 STEAP family member 3, metalloreductase
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)