increased spleen weight Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets (Mammalian Phenotype Ontology, MP_0004952)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004952
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Genes

104 gene mutations causing the increased spleen weight phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADD2 adducin 2 (beta)
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AHR aryl hydrocarbon receptor
AIRE autoimmune regulator
ALOX15 arachidonate 15-lipoxygenase
ANK1 ankyrin 1, erythrocytic
APOE apolipoprotein E
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCO2 beta-carotene oxygenase 2
BOK BCL2-related ovarian killer
C4A complement component 4A (Rodgers blood group)
CCNE1 cyclin E1
CD72 CD72 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CORO1A coronin, actin binding protein, 1A
CSF1R colony stimulating factor 1 receptor
CTSG cathepsin G
CXCR2 chemokine (C-X-C motif) receptor 2
CYCS cytochrome c, somatic
DBNL drebrin-like
DCC DCC netrin 1 receptor
DCK deoxycytidine kinase
DIAPH1 diaphanous-related formin 1
DIDO1 death inducer-obliterator 1
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EGLN1 egl-9 family hypoxia-inducible factor 1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EPB42 erythrocyte membrane protein band 4.2
EPGN epithelial mitogen
EPO erythropoietin
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FECH ferrochelatase
FOXP3 forkhead box P3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GBA glucosidase, beta, acid
GLMP glycosylated lysosomal membrane protein
GPI glucose-6-phosphate isomerase
HCST hematopoietic cell signal transducer
HK1 hexokinase 1
HSH2D hematopoietic SH2 domain containing
IL10RB interleukin 10 receptor, beta
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGAD integrin, alpha D
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KISS1R KISS1 receptor
KLF1 Kruppel-like factor 1 (erythroid)
KLF3 Kruppel-like factor 3 (basic)
LDHA lactate dehydrogenase A
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LTA lymphotoxin alpha
MARK2 MAP/microtubule affinity-regulating kinase 2
MARVELD2 MARVEL domain containing 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MFGE8 milk fat globule-EGF factor 8 protein
MIR144 microRNA 144
MIR451A microRNA 451a
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDFIP1 Nedd4 family interacting protein 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H4 nuclear receptor subfamily 1, group H, member 4
OCA2 oculocutaneous albinism II
PAPPA2 pappalysin 2
PFKM phosphofructokinase, muscle
PGM3 phosphoglucomutase 3
PLA2G15 phospholipase A2, group XV
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PREP prolyl endopeptidase
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
RC3H1 ring finger and CCCH-type domains 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPI1 Spi-1 proto-oncogene
SPIC Spi-C transcription factor (Spi-1/PU.1 related)
SPTA1 spectrin, alpha, erythrocytic 1
STEAP3 STEAP family member 3, metalloreductase
TAL1 T-cell acute lymphocytic leukemia 1
TBK1 TANK-binding kinase 1
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIP1 TNFAIP3 interacting protein 1
TPI1 triosephosphate isomerase 1
TRAF3IP2 TRAF3 interacting protein 2
TTC7A tetratricopeptide repeat domain 7A
ULK1 unc-51 like autophagy activating kinase 1
UNC93B1 unc-93 homolog B1 (C. elegans)
USP21 ubiquitin specific peptidase 21
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZFPM1 zinc finger protein, FOG family member 1