increased spleen red pulp amount Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation (Mammalian Phenotype Ontology, MP_0008476)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008476
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Genes

39 gene mutations causing the increased spleen red pulp amount phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ASL argininosuccinate lyase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD200 CD200 molecule
CHD2 chromodomain helicase DNA binding protein 2
DCC DCC netrin 1 receptor
EPB41 erythrocyte membrane protein band 4.1
FADS2 fatty acid desaturase 2
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
HK1 hexokinase 1
IL2 interleukin 2
IRF8 interferon regulatory factor 8
JAK2 Janus kinase 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PGM3 phosphoglucomutase 3
PRDX2 peroxiredoxin 2
PRF1 perforin 1 (pore forming protein)
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RASA3 RAS p21 protein activator 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SH3BP2 SH3-domain binding protein 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SPTB spectrin, beta, erythrocytic
STIM1 stromal interaction molecule 1
TNIP1 TNFAIP3 interacting protein 1
TPP2 tripeptidyl peptidase II
TTC7A tetratricopeptide repeat domain 7A
UROS uroporphyrinogen III synthase
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZFPM1 zinc finger protein, FOG family member 1