increased spleen germinal center size Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs (Mammalian Phenotype Ontology, MP_0008483)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008483
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Genes

13 gene mutations causing the increased spleen germinal center size phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BANK1 B-cell scaffold protein with ankyrin repeats 1
BECN1 beclin 1, autophagy related
FCAMR Fc receptor, IgA, IgM, high affinity
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
NCOA3 nuclear receptor coactivator 3
PKN1 protein kinase N1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGS13 regulator of G-protein signaling 13
SCARF1 scavenger receptor class F, member 1
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TYROBP TYRO protein tyrosine kinase binding protein