increased spleen germinal center number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs (Mammalian Phenotype Ontology, MP_0008481)
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20 gene mutations causing the increased spleen germinal center number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BANK1 B-cell scaffold protein with ankyrin repeats 1
BECN1 beclin 1, autophagy related
BHLHE40 basic helix-loop-helix family, member e40
C4A complement component 4A (Rodgers blood group)
C5AR1 complement component 5a receptor 1
ESR1 estrogen receptor 1
FCAMR Fc receptor, IgA, IgM, high affinity
GABPB2 GA binding protein transcription factor, beta subunit 2
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
LAT linker for activation of T cells
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
PGAP3 post-GPI attachment to proteins 3
POLB polymerase (DNA directed), beta
PRKCD protein kinase C, delta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGS13 regulator of G-protein signaling 13
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TYROBP TYRO protein tyrosine kinase binding protein