increased sensitivity to induced cell death Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level (Mammalian Phenotype Ontology, MP_0008943)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008943
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Genes

139 gene mutations causing the increased sensitivity to induced cell death phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHSP alpha hemoglobin stabilizing protein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATF6 activating transcription factor 6
ATF6B activating transcription factor 6 beta
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CASP3 caspase 3, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CCNG1 cyclin G1
CCS copper chaperone for superoxide dismutase
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHD2 chromodomain helicase DNA binding protein 2
CLP1 cleavage and polyadenylation factor I subunit 1
COPS6 COP9 signalosome subunit 6
CP ceruloplasmin (ferroxidase)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CREBBP CREB binding protein
CRYBB2 crystallin, beta B2
CTH cystathionine gamma-lyase
CUL4A cullin 4A
DCLRE1C DNA cross-link repair 1C
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FEN1 flap structure-specific endonuclease 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GPX1 glutathione peroxidase 1
GPX7 glutathione peroxidase 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGN1 high mobility group nucleosome binding domain 1
ING1 inhibitor of growth family, member 1
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
IVNS1ABP influenza virus NS1A binding protein
JUND jun D proto-oncogene
LIG4 ligase IV, DNA, ATP-dependent
MAPKAP1 mitogen-activated protein kinase associated protein 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR144 microRNA 144
MIR451A microRNA 451a
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTA1 metastasis associated 1
MTF1 metal-regulatory transcription factor 1
MTFR1 mitochondrial fission regulator 1
MUS81 MUS81 structure-specific endonuclease subunit
MXD3 MAX dimerization protein 3
NBN nibrin
NFE2L2 nuclear factor, erythroid 2-like 2
NHEJ1 nonhomologous end-joining factor 1
NINJ1 ninjurin 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PINK1 PTEN induced putative kinase 1
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
POLK polymerase (DNA directed) kappa
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAD9B RAD9 homolog B (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
REG1B regenerating islet-derived 1 beta
RGN regucalcin
RIF1 replication timing regulatory factor 1
RIT1 Ras-like without CAAX 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SESN2 sestrin 2
SGOL1 shugoshin-like 1 (S. pombe)
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SIRT7 sirtuin 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
SMC1A structural maintenance of chromosomes 1A
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TPT1 tumor protein, translationally-controlled 1
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRIP12 thyroid hormone receptor interactor 12
TROVE2 TROVE domain family, member 2
TYR tyrosinase
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP47 ubiquitin specific peptidase 47
VASN vasorin
WRN Werner syndrome, RecQ helicase-like
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFP36 ZFP36 ring finger protein