increased metastatic potential Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it (Mammalian Phenotype Ontology, MP_0001272)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001272
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Genes

28 gene mutations causing the increased metastatic potential phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APC adenomatous polyposis coli
ATF2 activating transcription factor 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CD226 CD226 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CST3 cystatin C
E2F1 E2F transcription factor 1
EPHA2 EPH receptor A2
FASLG Fas ligand (TNF superfamily, member 6)
HIC1 hypermethylated in cancer 1
HMGN1 high mobility group nucleosome binding domain 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LEP leptin
LEPR leptin receptor
MSMB microseminoprotein, beta-
RB1 retinoblastoma 1
RNF19B ring finger protein 19B
SMAD3 SMAD family member 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated