increased mean systemic arterial blood pressure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the average arterial pressure during a single cardiac cycle (Mammalian Phenotype Ontology, MP_0004875)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004875
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Genes

35 gene mutations causing the increased mean systemic arterial blood pressure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
AGTR2 angiotensin II receptor, type 2
AGTRAP angiotensin II receptor-associated protein
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
CALCB calcitonin-related polypeptide beta
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CTSA cathepsin A
DDAH1 dimethylarginine dimethylaminohydrolase 1
DLL1 delta-like 1 (Drosophila)
DRD2 dopamine receptor D2
EDN1 endothelin 1
EDNRB endothelin receptor type B
ELN elastin
GDNF glial cell derived neurotrophic factor
GPER1 G protein-coupled estrogen receptor 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LEPR leptin receptor
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR1 natriuretic peptide receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PRKG1 protein kinase, cGMP-dependent, type I
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMTN smoothelin
THBS1 thrombospondin 1
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WNK1 WNK lysine deficient protein kinase 1