increased mast cell degranulation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell (Mammalian Phenotype Ontology, MP_0008764)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008764
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Genes

11 gene mutations causing the increased mast cell degranulation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CCR3 chemokine (C-C motif) receptor 3
CORO1A coronin, actin binding protein, 1A
DUSP1 dual specificity phosphatase 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT2 linker for activation of T cells family, member 2
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
MMP24 matrix metallopeptidase 24 (membrane-inserted)
NF1 neurofibromin 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
SPRED1 sprouty-related, EVH1 domain containing 1