increased malignant tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal incidence of locally invasive, destructive and metastatic tumors (Mammalian Phenotype Ontology, MP_0002018)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002018
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Genes

196 gene mutations causing the increased malignant tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACPP acid phosphatase, prostate
ACTB actin, beta
AHR aryl hydrocarbon receptor
AMHR2 anti-Mullerian hormone receptor, type II
ANXA7 annexin A7
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BECN1 beclin 1, autophagy related
BHLHA15 basic helix-loop-helix family, member a15
BHMT betaine--homocysteine S-methyltransferase
BIN3 bridging integrator 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CABLES1 Cdk5 and Abl enzyme substrate 1
CASC1 cancer susceptibility candidate 1
CBX7 chromobox homolog 7
CCNDBP1 cyclin D-type binding-protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CERS2 ceramide synthase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CREBBP CREB binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL9 cullin 9
CXCR6 chemokine (C-X-C motif) receptor 6
CYTIP cytohesin 1 interacting protein
DCC DCC netrin 1 receptor
DCLRE1A DNA cross-link repair 1A
DDB2 damage-specific DNA binding protein 2, 48kDa
DGKD diacylglycerol kinase, delta 130kDa
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERRFI1 ERBB receptor feedback inhibitor 1
EXO1 exonuclease 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FANCD2 Fanconi anemia, complementation group D2
FASLG Fas ligand (TNF superfamily, member 6)
FBXO4 F-box protein 4
FEN1 flap structure-specific endonuclease 1
FHIT fragile histidine triad
FLT3 fms-related tyrosine kinase 3
FOXM1 forkhead box M1
FOXN1 forkhead box N1
FOXO3 forkhead box O3
FSHR follicle stimulating hormone receptor
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNMT glycine N-methyltransferase
GON4L gon-4-like (C. elegans)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX7 glutathione peroxidase 7
GRM1 glutamate receptor, metabotropic 1
GTF2IRD1 GTF2I repeat domain containing 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HIC1 hypermethylated in cancer 1
HMGN1 high mobility group nucleosome binding domain 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IL10 interleukin 10
IL12RB2 interleukin 12 receptor, beta 2
ING2 inhibitor of growth family, member 2
IQGAP2 IQ motif containing GTPase activating protein 2
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LATS1 large tumor suppressor kinase 1
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LMO7 LIM domain 7
LTBP4 latent transforming growth factor beta binding protein 4
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MC4R melanocortin 4 receptor
MCM4 minichromosome maintenance complex component 4
MCM9 minichromosome maintenance complex component 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR122 microRNA 122
MLH1 mutL homolog 1
MMP8 matrix metallopeptidase 8
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
MUC2 mucin 2, oligomeric mucus/gel-forming
MUS81 MUS81 structure-specific endonuclease subunit
MZF1 myeloid zinc finger 1
NBN nibrin
NCOA5 nuclear receptor coactivator 5
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NKX2-8 NK2 homeobox 8
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PAQR3 progestin and adipoQ receptor family member III
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLH polymerase (DNA directed), eta
PPARD peroxisome proliferator-activated receptor delta
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRLR prolactin receptor
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
RECQL4 RecQ protein-like 4
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RGPD1 RANBP2-like and GRIP domain containing 1
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A4 S100 calcium binding protein A4
SAV1 salvador family WW domain containing protein 1
SCRIB scribbled planar cell polarity protein
SFN stratifin
SIRT2 sirtuin 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMAD3 SMAD family member 3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SSBP2 single-stranded DNA binding protein 2
STAG1 stromal antigen 1
STK11 serine/threonine kinase 11
STK4 serine/threonine kinase 4
TES testin LIM domain protein
TFF1 trefoil factor 1
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THRB thyroid hormone receptor, beta
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR2 toll-like receptor 2
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM24 tripartite motif containing 24
TRIM62 tripartite motif containing 62
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUSC2 tumor suppressor candidate 2
TXNIP thioredoxin interacting protein
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
USP44 ubiquitin specific peptidase 44
WIF1 WNT inhibitory factor 1
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C