increased lung tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of neoplasms in the lung, usually in the form of a distinct mass, in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0008014)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008014
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Genes

87 gene mutations causing the increased lung tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATAD5 ATPase family, AAA domain containing 5
AURKA aurora kinase A
BECN1 beclin 1, autophagy related
BIN3 bridging integrator 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASC1 cancer susceptibility candidate 1
CBX7 chromobox homolog 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHUK conserved helix-loop-helix ubiquitous kinase
CUL9 cullin 9
DCLRE1A DNA cross-link repair 1A
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX7 glutathione peroxidase 7
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HIC1 hypermethylated in cancer 1
IFNG interferon, gamma
IL12RB2 interleukin 12 receptor, beta 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LMO7 LIM domain 7
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
MSH2 mutS homolog 2
NBN nibrin
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NKX2-8 NK2 homeobox 8
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
RGPD1 RANBP2-like and GRIP domain containing 1
RINT1 RAD50 interactor 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A4 S100 calcium binding protein A4
SCRIB scribbled planar cell polarity protein
SIRT2 sirtuin 2
SMAD4 SMAD family member 4
SMAD9 SMAD family member 9
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SSBP2 single-stranded DNA binding protein 2
TGFBI transforming growth factor, beta-induced, 68kDa
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM62 tripartite motif containing 62
TSC2 tuberous sclerosis 2
USP44 ubiquitin specific peptidase 44
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C