increased lung carcinoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008714
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Genes

63 gene mutations causing the increased lung carcinoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATAD5 ATPase family, AAA domain containing 5
AURKA aurora kinase A
BECN1 beclin 1, autophagy related
BIN3 bridging integrator 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG3 BTG family, member 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASC1 cancer susceptibility candidate 1
CBX7 chromobox homolog 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
F3 coagulation factor III (thromboplastin, tissue factor)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX7 glutathione peroxidase 7
HCK HCK proto-oncogene, Src family tyrosine kinase
HIC1 hypermethylated in cancer 1
IFNG interferon, gamma
IL12RB2 interleukin 12 receptor, beta 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LMO7 LIM domain 7
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
NBN nibrin
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RGPD1 RANBP2-like and GRIP domain containing 1
RINT1 RAD50 interactor 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A4 S100 calcium binding protein A4
SCRIB scribbled planar cell polarity protein
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SRPX sushi-repeat containing protein, X-linked
TGFBI transforming growth factor, beta-induced, 68kDa
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM62 tripartite motif containing 62
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C