increased liver triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver (Mammalian Phenotype Ontology, MP_0009355)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009355
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Genes

63 gene mutations causing the increased liver triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABHD5 abhydrolase domain containing 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
APOC1 apolipoprotein C-I
BCO2 beta-carotene oxygenase 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHKA choline kinase alpha
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERCC1 excision repair cross-complementation group 1
FADS2 fatty acid desaturase 2
FFAR1 free fatty acid receptor 1
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FOXA2 forkhead box A2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR12 G protein-coupled receptor 12
GPRC6A G protein-coupled receptor, class C, group 6, member A
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HRH1 histamine receptor H1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IL10 interleukin 10
KMT2B lysine (K)-specific methyltransferase 2B
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPI lipase, member I
LPIN1 lipin 1
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MIR122 microRNA 122
MTTP microsomal triglyceride transfer protein
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PANK1 pantothenate kinase 1
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN5 perilipin 5
PNPLA2 patatin-like phospholipase domain containing 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRLH prolactin releasing hormone
PROX1 prospero homeobox 1
RGN regucalcin
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SESN2 sestrin 2
SIRT3 sirtuin 3
SIRT7 sirtuin 7
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
STEAP4 STEAP family member 4