increased large intestine adenocarcinoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal incidence of a malignant neoplasm of epithelial cells in the large intestine (Mammalian Phenotype Ontology, MP_0009310)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009310
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Genes

7 gene mutations causing the increased large intestine adenocarcinoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APC adenomatous polyposis coli
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
IL10 interleukin 10
LIG4 ligase IV, DNA, ATP-dependent
LTBP4 latent transforming growth factor beta binding protein 4
POLE polymerase (DNA directed), epsilon, catalytic subunit
TGFB1 transforming growth factor, beta 1