increased interleukin-6 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts (Mammalian Phenotype Ontology, MP_0008705)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008705
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Genes

65 gene mutations causing the increased interleukin-6 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ADORA2B adenosine A2b receptor
AIRE autoimmune regulator
APOE apolipoprotein E
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG9A autophagy related 9A
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAG4 BCL2-associated athanogene 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
DMD dystrophin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
FOS FBJ murine osteosarcoma viral oncogene homolog
GRN granulin
HSPA1B heat shock 70kDa protein 1B
HSPB1 heat shock 27kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNGR1 interferon gamma receptor 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12RB2 interleukin 12 receptor, beta 2
IL17RA interleukin 17 receptor A
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
IRAK3 interleukin-1 receptor-associated kinase 3
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP28 matrix metallopeptidase 28
MOG myelin oligodendrocyte glycoprotein
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRX1 NLR family member X1
PBK PDZ binding kinase
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POMC proopiomelanocortin
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKCD protein kinase C, delta
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RHBDD3 rhomboid domain containing 3
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLPI secretory leukocyte peptidase inhibitor
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TLR8 toll-like receptor 8
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNIP1 TNFAIP3 interacting protein 1
TRAFD1 TRAF-type zinc finger domain containing 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TYROBP TYRO protein tyrosine kinase binding protein
USP18 ubiquitin specific peptidase 18
USP25 ubiquitin specific peptidase 25
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H12D zinc finger CCCH-type containing 12D