increased interleukin-4 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells (Mammalian Phenotype Ontology, MP_0008699)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008699
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Genes

48 gene mutations causing the increased interleukin-4 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD274 CD274 molecule
CD300LF CD300 molecule-like family member f
CISH cytokine inducible SH2-containing protein
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSE cathepsin E
DMD dystrophin
DTX1 deltex 1, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FLG filaggrin
GPR34 G protein-coupled receptor 34
GPR84 G protein-coupled receptor 84
HAVCR1 hepatitis A virus cellular receptor 1
HCST hematopoietic cell signal transducer
HRH1 histamine receptor H1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL27RA interleukin 27 receptor, alpha
IL4R interleukin 4 receptor
IL6 interleukin 6
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
MARK2 MAP/microtubule affinity-regulating kinase 2
MBP myelin basic protein
MEFV Mediterranean fever
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP9 matrix metallopeptidase 9
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
POU2AF1 POU class 2 associating factor 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
RAD50 RAD50 homolog (S. cerevisiae)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SH2D2A SH2 domain containing 2A
SIRT7 sirtuin 7
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
STK4 serine/threonine kinase 4
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13