increased interleukin-2 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes (Mammalian Phenotype Ontology, MP_0008687)
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38 gene mutations causing the increased interleukin-2 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DGKA diacylglycerol kinase, alpha 80kDa
DMD dystrophin
DTX1 deltex 1, E3 ubiquitin ligase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR34 G protein-coupled receptor 34
HSH2D hematopoietic SH2 domain containing
IFNG interferon, gamma
IL12B interleukin 12B
IL15RA interleukin 15 receptor, alpha
IL20RB interleukin 20 receptor beta
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
MBP myelin basic protein
MEFV Mediterranean fever
MMP1 matrix metallopeptidase 1
MOG myelin oligodendrocyte glycoprotein
NDFIP1 Nedd4 family interacting protein 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PDCD1LG2 programmed cell death 1 ligand 2
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SIT1 signaling threshold regulating transmembrane adaptor 1
SOCS3 suppressor of cytokine signaling 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VIPR2 vasoactive intestinal peptide receptor 2