increased interleukin-12 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells (Mammalian Phenotype Ontology, MP_0008663)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008663
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Genes

25 gene mutations causing the increased interleukin-12 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
CCR1 chemokine (C-C motif) receptor 1
CD300LF CD300 molecule-like family member f
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
DMD dystrophin
DUSP4 dual specificity phosphatase 4
GPR34 G protein-coupled receptor 34
GRN granulin
IFNG interferon, gamma
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MEFV Mediterranean fever
MSR1 macrophage scavenger receptor 1
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
PILRB paired immunoglobin-like type 2 receptor beta
PINK1 PTEN induced putative kinase 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SIRT7 sirtuin 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAFD1 TRAF-type zinc finger domain containing 1