increased interleukin-10 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation (Mammalian Phenotype Ontology, MP_0008660)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008660
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Genes

29 gene mutations causing the increased interleukin-10 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
CCL13 chemokine (C-C motif) ligand 13
CCR4 chemokine (C-C motif) receptor 4
CD300A CD300a molecule
CD44 CD44 molecule (Indian blood group)
CLEC4D C-type lectin domain family 4, member D
DUSP4 dual specificity phosphatase 4
FLG filaggrin
GFI1 growth factor independent 1 transcription repressor
GPR34 G protein-coupled receptor 34
GRN granulin
HAVCR1 hepatitis A virus cellular receptor 1
IFNG interferon, gamma
IL13RA2 interleukin 13 receptor, alpha 2
ITK IL2-inducible T-cell kinase
LAT2 linker for activation of T cells family, member 2
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR155 microRNA 155
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PILRB paired immunoglobin-like type 2 receptor beta
PINK1 PTEN induced putative kinase 1
PRF1 perforin 1 (pore forming protein)
RGS16 regulator of G-protein signaling 16
SPP1 secreted phosphoprotein 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
ZC3H12D zinc finger CCCH-type containing 12D