increased interleukin-1 beta secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane (Mammalian Phenotype Ontology, MP_0008657)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008657
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Genes

30 gene mutations causing the increased interleukin-1 beta secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BPIFA1 BPI fold containing family A, member 1
CASP12 caspase 12 (gene/pseudogene)
CD300LF CD300 molecule-like family member f
CD44 CD44 molecule (Indian blood group)
CLEC6A C-type lectin domain family 6, member A
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
GFI1 growth factor independent 1 transcription repressor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEFV Mediterranean fever
MMP7 matrix metallopeptidase 7
MUC2 mucin 2, oligomeric mucus/gel-forming
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NOD2 nucleotide-binding oligomerization domain containing 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PINK1 PTEN induced putative kinase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SOCS2 suppressor of cytokine signaling 2
SSTR4 somatostatin receptor 4
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
ZC3H12A zinc finger CCCH-type containing 12A