increased interferon-gamma secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation (Mammalian Phenotype Ontology, MP_0008566)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008566
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Genes

100 gene mutations causing the increased interferon-gamma secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CASP12 caspase 12 (gene/pseudogene)
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD86 CD86 molecule
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
CLNK cytokine-dependent hematopoietic cell linker
COMT catechol-O-methyltransferase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DMD dystrophin
DTX1 deltex 1, E3 ubiquitin ligase
DUSP10 dual specificity phosphatase 10
E2F1 E2F transcription factor 1
EBI3 Epstein-Barr virus induced 3
EFS embryonal Fyn-associated substrate
FLG filaggrin
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR15 G protein-coupled receptor 15
GPR34 G protein-coupled receptor 34
HCST hematopoietic cell signal transducer
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICOSLG inducible T-cell co-stimulator ligand
IDO1 indoleamine 2,3-dioxygenase 1
IFNB1 interferon, beta 1, fibroblast
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL4 interleukin 4
IL5 interleukin 5
IL6ST interleukin 6 signal transducer
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LGALS1 lectin, galactoside-binding, soluble, 1
MARCO macrophage receptor with collagenous structure
MARK2 MAP/microtubule affinity-regulating kinase 2
MBP myelin basic protein
MEFV Mediterranean fever
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MUC2 mucin 2, oligomeric mucus/gel-forming
NFIL3 nuclear factor, interleukin 3 regulated
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
PDCD1LG2 programmed cell death 1 ligand 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PECAM1 platelet/endothelial cell adhesion molecule 1
PILRB paired immunoglobin-like type 2 receptor beta
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RHBDD3 rhomboid domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
SH2D1B SH2 domain containing 1B
SIT1 signaling threshold regulating transmembrane adaptor 1
SOCS2 suppressor of cytokine signaling 2
SSTR4 somatostatin receptor 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
STX11 syntaxin 11
TGFB1 transforming growth factor, beta 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM27 tripartite motif containing 27
TSC22D3 TSC22 domain family, member 3
TSLP thymic stromal lymphopoietin
VIPR2 vasoactive intestinal peptide receptor 2
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB7B zinc finger and BTB domain containing 7B
ZC3H12A zinc finger CCCH-type containing 12A