increased insulin secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater production or release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids (Mammalian Phenotype Ontology, MP_0003058)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003058
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Genes

32 gene mutations causing the increased insulin secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
AQP7 aquaporin 7
ATF4 activating transcription factor 4
ATXN2 ataxin 2
CCDC80 coiled-coil domain containing 80
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
DPP4 dipeptidyl-peptidase 4
GHRL ghrelin/obestatin prepropeptide
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
HADH hydroxyacyl-CoA dehydrogenase
HPRT1 hypoxanthine phosphoribosyltransferase 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LEP leptin
LEPR leptin receptor
MAPK13 mitogen-activated protein kinase 13
MIR184 microRNA 184
MIR375 microRNA 375
OPRM1 opioid receptor, mu 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PGR progesterone receptor
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
SIRT1 sirtuin 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SSTR5 somatostatin receptor 5
SYTL4 synaptotagmin-like 4
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2