increased glucagon secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes (Mammalian Phenotype Ontology, MP_0002710)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002710
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Genes

7 gene mutations causing the increased glucagon secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CADPS2 Ca++-dependent secretion activator 2
GCGR glucagon receptor
LEPR leptin receptor
MIR375 microRNA 375
PDX1 pancreatic and duodenal homeobox 1
THRA thyroid hormone receptor, alpha
WFS1 Wolfram syndrome 1 (wolframin)