increased energy expenditure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten (Mammalian Phenotype Ontology, MP_0004889)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004889
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Genes

135 gene mutations causing the increased energy expenditure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACER1 alkaline ceramidase 1
ACOT11 acyl-CoA thioesterase 11
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGTR2 angiotensin II receptor, type 2
AHNAK AHNAK nucleoprotein
AHSG alpha-2-HS-glycoprotein
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
ARID5B AT rich interactive domain 5B (MRF1-like)
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX1 chromobox homolog 1
CCDC7 coiled-coil domain containing 7
CCKBR cholecystokinin B receptor
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDH23 cadherin-related 23
CENPJ centromere protein J
CERS6 ceramide synthase 6
CHD7 chromodomain helicase DNA binding protein 7
CIDEC cell death-inducing DFFA-like effector c
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL5A3 collagen, type V, alpha 3
CRBN cereblon
CREBBP CREB binding protein
CRTC3 CREB regulated transcription coactivator 3
DBN1 drebrin 1
DGAT1 diacylglycerol O-acyltransferase 1
DLG2 discs, large homolog 2 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DNASE1L2 deoxyribonuclease I-like 2
DUSP1 dual specificity phosphatase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESRRA estrogen-related receptor alpha
FABP2 fatty acid binding protein 2, intestinal
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM134C family with sequence similarity 134, member C
FOXS1 forkhead box S1
FTO fat mass and obesity associated
GALP galanin-like peptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF3 growth differentiation factor 3
GHSR growth hormone secretagogue receptor
GPR21 G protein-coupled receptor 21
GPR50 G protein-coupled receptor 50
GPSM1 G-protein signaling modulator 1
HADH hydroxyacyl-CoA dehydrogenase
HMGA2 high mobility group AT-hook 2
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LCLAT1 lysocardiolipin acyltransferase 1
LGALS12 lectin, galactoside-binding, soluble, 12
LIPE lipase, hormone-sensitive
LRP6 low density lipoprotein receptor-related protein 6
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBOAT4 membrane bound O-acyltransferase domain containing 4
MCHR1 melanin-concentrating hormone receptor 1
MFSD2A major facilitator superfamily domain containing 2A
MIR378A microRNA 378a
MOGAT2 monoacylglycerol O-acyltransferase 2
MTM1 myotubularin 1
MYO6 myosin VI
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NMUR2 neuromedin U receptor 2
NPC1L1 NPC1-like 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
PASK PAS domain containing serine/threonine kinase
PDE10A phosphodiesterase 10A
PITX3 paired-like homeodomain 3
PLIN1 perilipin 1
PLIN2 perilipin 2
PNLIP pancreatic lipase
PNRC2 proline-rich nuclear receptor coactivator 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAD18 RAD18 E3 ubiquitin protein ligase
RCAN2 regulator of calcineurin 2
RGPD1 RANBP2-like and GRIP domain containing 1
RLN3 relaxin 3
RMI1 RecQ mediated genome instability 1
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC3 syndecan 3
SERTAD2 SERTA domain containing 2
SGMS2 sphingomyelin synthase 2
SIK3 SIK family kinase 3
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC38A10 solute carrier family 38, member 10
SOCS3 suppressor of cytokine signaling 3
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TLR2 toll-like receptor 2
TMPRSS15 transmembrane protease, serine 15
TNF tumor necrosis factor
TNIK TRAF2 and NCK interacting kinase
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
USH1C Usher syndrome 1C (autosomal recessive, severe)
WDR47 WD repeat domain 47
ZC3HC1 zinc finger, C3HC-type containing 1