increased dn3 thymocyte number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. (Mammalian Phenotype Ontology, MP_0010133)
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7 gene mutations causing the increased dn3 thymocyte number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CDK6 cyclin-dependent kinase 6
PTCRA pre T-cell antigen receptor alpha
RAG2 recombination activating gene 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
SYK spleen tyrosine kinase
VAV1 vav 1 guanine nucleotide exchange factor