increased circulating triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver (Mammalian Phenotype Ontology, MP_0001552)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001552
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Genes

122 gene mutations causing the increased circulating triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACACB acetyl-CoA carboxylase beta
ACOT11 acyl-CoA thioesterase 11
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALMS1 Alstrom syndrome protein 1
ALPI alkaline phosphatase, intestinal
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP8 aquaporin 8
AQP9 aquaporin 9
BGLAP bone gamma-carboxyglutamate (gla) protein
BRD2 bromodomain containing 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP19 centrosomal protein 19kDa
CLOCK clock circadian regulator
COL18A1 collagen, type XVIII, alpha 1
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FABP3 fatty acid binding protein 3, muscle and heart
FGF21 fibroblast growth factor 21
FOXA2 forkhead box A2
FTO fat mass and obesity associated
G6PC glucose-6-phosphatase, catalytic subunit
GCK glucokinase (hexokinase 4)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GPR26 G protein-coupled receptor 26
HADH hydroxyacyl-CoA dehydrogenase
IL21R interleukin 21 receptor
IL25 interleukin 25
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KDM3A lysine (K)-specific demethylase 3A
KMT2B lysine (K)-specific methyltransferase 2B
LAMB2 laminin, beta 2 (laminin S)
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LIPG lipase, endothelial
LIPI lipase, member I
LMF1 lipase maturation factor 1
LPIN1 lipin 1
LPL lipoprotein lipase
LYPD3 LY6/PLAUR domain containing 3
MECP2 methyl CpG binding protein 2
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR378A microRNA 378a
MUC2 mucin 2, oligomeric mucus/gel-forming
MYO7A myosin VIIA
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUAK2 NUAK family, SNF1-like kinase, 2
OCA2 oculocutaneous albinism II
OMA1 OMA1 zinc metallopeptidase
OSBPL8 oxysterol binding protein-like 8
OSMR oncostatin M receptor
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PLAGL2 pleiomorphic adenoma gene-like 2
PLSCR3 phospholipid scramblase 3
PLVAP plasmalemma vesicle associated protein
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRF1 perforin 1 (pore forming protein)
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PTRF polymerase I and transcript release factor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSBN1 round spermatid basic protein 1
SCARB1 scavenger receptor class B, member 1
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SIK3 SIK family kinase 3
SIRT3 sirtuin 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SOAT2 sterol O-acyltransferase 2
STEAP4 STEAP family member 4
TLR5 toll-like receptor 5
TRA2B transformer 2 beta homolog (Drosophila)
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TUB tubby bipartite transcription factor
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
VLDLR very low density lipoprotein receptor
WRN Werner syndrome, RecQ helicase-like
ZEB1 zinc finger E-box binding homeobox 1