increased circulating interleukin-10 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation (Mammalian Phenotype Ontology, MP_0008593)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008593
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Genes

16 gene mutations causing the increased circulating interleukin-10 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
CCL13 chemokine (C-C motif) ligand 13
DUSP1 dual specificity phosphatase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
IL6 interleukin 6
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
NFIL3 nuclear factor, interleukin 3 regulated
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSMR oncostatin M receptor
PCSK1 proprotein convertase subtilisin/kexin type 1
PRF1 perforin 1 (pore forming protein)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SIRT3 sirtuin 3
TBK1 TANK-binding kinase 1
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2