increased circulating insulin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002079
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Genes

143 gene mutations causing the increased circulating insulin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
ALX3 ALX homeobox 3
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
ANXA1 annexin A1
AQP7 aquaporin 7
ASIP agouti signaling protein
ATF4 activating transcription factor 4
ATXN2 ataxin 2
BAD BCL2-associated agonist of cell death
BBS4 Bardet-Biedl syndrome 4
BDNF brain-derived neurotrophic factor
BRD2 bromodomain containing 2
BRS3 bombesin-like receptor 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C5AR2 complement component 5a receptor 2
CARTPT CART prepropeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CTF1 cardiotrophin 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DPP4 dipeptidyl-peptidase 4
FABP2 fatty acid binding protein 2, intestinal
FAM3B family with sequence similarity 3, member B
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FOXO1 forkhead box O1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAST gastrin
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GLIS3 GLIS family zinc finger 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPBAR1 G protein-coupled bile acid receptor 1
GPR26 G protein-coupled receptor 26
GUCY2C guanylate cyclase 2C
HADH hydroxyacyl-CoA dehydrogenase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDC histidine decarboxylase
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KDM3A lysine (K)-specific demethylase 3A
KMT2B lysine (K)-specific methyltransferase 2B
KPTN kaptin (actin binding protein)
LCMT1 leucine carboxyl methyltransferase 1
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LPIN1 lipin 1
MAPK13 mitogen-activated protein kinase 13
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MEN1 multiple endocrine neoplasia I
MIR184 microRNA 184
MLXIPL MLX interacting protein-like
MRAP2 melanocortin 2 receptor accessory protein 2
MYO7A myosin VIIA
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NPBWR1 neuropeptides B/W receptor 1
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCA2 oculocutaneous albinism II
OPRM1 opioid receptor, mu 1
OSMR oncostatin M receptor
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPK1 3-phosphoinositide dependent protein kinase 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLIN1 perilipin 1
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
PYY peptide YY
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SIM1 single-minded family bHLH transcription factor 1
SIRT3 sirtuin 3
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SNX5 sorting nexin 5
SOCS2 suppressor of cytokine signaling 2
SST somatostatin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STX4 syntaxin 4
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TERF2IP telomeric repeat binding factor 2, interacting protein
THRA thyroid hormone receptor, alpha
TLR5 toll-like receptor 5
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TUB tubby bipartite transcription factor
TYK2 tyrosine kinase 2
WDTC1 WD and tetratricopeptide repeats 1
WRN Werner syndrome, RecQ helicase-like
ZEB1 zinc finger E-box binding homeobox 1