increased circulating glucose level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source (Mammalian Phenotype Ontology, MP_0005559)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005559
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Genes

204 gene mutations causing the increased circulating glucose level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADORA2B adenosine A2b receptor
ADRA1B adrenoceptor alpha 1B
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGER advanced glycosylation end product-specific receptor
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
ALX3 ALX homeobox 3
ANGPTL6 angiopoietin-like 6
APOC3 apolipoprotein C-III
ASIP agouti signaling protein
ATN1 atrophin 1
BAD BCL2-associated agonist of cell death
BBS12 Bardet-Biedl syndrome 12
BBS4 Bardet-Biedl syndrome 4
BBS5 Bardet-Biedl syndrome 5
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP4 bone morphogenetic protein 4
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD33 CD33 molecule
CDH23 cadherin-related 23
CDK4 cyclin-dependent kinase 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP19 centrosomal protein 19kDa
CINP cyclin-dependent kinase 2 interacting protein
CLOCK clock circadian regulator
COL5A3 collagen, type V, alpha 3
CORT cortistatin
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTF1 cardiotrophin 1
CTHRC1 collagen triple helix repeat containing 1
CTSB cathepsin B
CTSS cathepsin S
CTSV cathepsin V
CXCR3 chemokine (C-X-C motif) receptor 3
CYB5R4 cytochrome b5 reductase 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDR2 discoidin domain receptor tyrosine kinase 2
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERO1LB ERO1-like beta (S. cerevisiae)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F10 coagulation factor X
FFAR1 free fatty acid receptor 1
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FOXO1 forkhead box O1
FTO fat mass and obesity associated
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCG glucagon
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHR growth hormone receptor
GIPR gastric inhibitory polypeptide receptor
GLIS3 GLIS family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GPI glucose-6-phosphate isomerase
GPR12 G protein-coupled receptor 12
GPR26 G protein-coupled receptor 26
GPR39 G protein-coupled receptor 39
GPRC6A G protein-coupled receptor, class C, group 6, member A
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGN3 high mobility group nucleosomal binding domain 3
HNF1A HNF1 homeobox A
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IGFBP3 insulin-like growth factor binding protein 3
IL4 interleukin 4
IL6 interleukin 6
ILDR2 immunoglobulin-like domain containing receptor 2
INS insulin
INSL5 insulin-like 5
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KDM3A lysine (K)-specific demethylase 3A
KISS1R KISS1 receptor
KMT2B lysine (K)-specific methyltransferase 2B
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPE lipase, hormone-sensitive
LPIN1 lipin 1
MACROD2 MACRO domain containing 2
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARC2 mitochondrial amidoxime reducing component 2
MC4R melanocortin 4 receptor
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGMT O-6-methylguanine-DNA methyltransferase
MIR375 microRNA 375
MLXIPL MLX interacting protein-like
MPG N-methylpurine-DNA glycosylase
MYD88 myeloid differentiation primary response 88
MYO7A myosin VIIA
NAGK N-acetylglucosamine kinase
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NCOR2 nuclear receptor corepressor 2
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NKX2-2 NK2 homeobox 2
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NPBWR1 neuropeptides B/W receptor 1
NPY1R neuropeptide Y receptor Y1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1I3 nuclear receptor subfamily 1, group I, member 3
NRCAM neuronal cell adhesion molecule
NUAK2 NUAK family, SNF1-like kinase, 2
OCA2 oculocutaneous albinism II
ONECUT1 one cut homeobox 1
OSMR oncostatin M receptor
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PARG poly (ADP-ribose) glycohydrolase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD1LG2 programmed cell death 1 ligand 2
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLSCR3 phospholipid scramblase 3
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PRADC1 protease-associated domain containing 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCI protein kinase C, iota
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLHR prolactin releasing hormone receptor
PTTG1 pituitary tumor-transforming 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM4 RNA binding motif protein 4
RBM4B RNA binding motif protein 4B
RGS10 regulator of G-protein signaling 10
RIMS2 regulating synaptic membrane exocytosis 2
RNASE10 ribonuclease, RNase A family, 10 (non-active)
RNF183 ring finger protein 183
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCTR secretin receptor
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGMS1 sphingomyelin synthase 1
SH2B1 SH2B adaptor protein 1
SIDT2 SID1 transmembrane family, member 2
SIM1 single-minded family bHLH transcription factor 1
SIRT3 sirtuin 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SLX4 SLX4 structure-specific endonuclease subunit
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STEAP3 STEAP family member 3, metalloreductase
STEAP4 STEAP family member 4
STK11 serine/threonine kinase 11
STXBP3 syntaxin binding protein 3
SYK spleen tyrosine kinase
TBC1D4 TBC1 domain family, member 4
TBKBP1 TBK1 binding protein 1
TBX19 T-box 19
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
TLR3 toll-like receptor 3
TRH thyrotropin-releasing hormone
TRHR thyrotropin-releasing hormone receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WRN Werner syndrome, RecQ helicase-like