increased circulating estradiol level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals (Mammalian Phenotype Ontology, MP_0005182)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005182
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Genes

14 gene mutations causing the increased circulating estradiol level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BGLAP bone gamma-carboxyglutamate (gla) protein
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
ESR1 estrogen receptor 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPRC6A G protein-coupled receptor, class C, group 6, member A
INHA inhibin, alpha
LHCGR luteinizing hormone/choriogonadotropin receptor
NCOA1 nuclear receptor coactivator 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1H3 nuclear receptor subfamily 1, group H, member 3
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TIMP1 TIMP metallopeptidase inhibitor 1