increased cell proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the expansion rate of a cell population by cell division (Mammalian Phenotype Ontology, MP_0000351)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000351
Similar Terms
Downloads & Tools

Genes

138 gene mutations causing the increased cell proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACP1 acid phosphatase 1, soluble
ADRA2B adrenoceptor alpha 2B
AGR2 anterior gradient 2
ALMS1 Alstrom syndrome protein 1
AMBRA1 autophagy/beclin-1 regulator 1
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ASXL1 additional sex combs like transcriptional regulator 1
BAG6 BCL2-associated athanogene 6
BARX1 BARX homeobox 1
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CACYBP calcyclin binding protein
CAV1 caveolin 1, caveolae protein, 22kDa
CBX7 chromobox homolog 7
CCNE1 cyclin E1
CD28 CD28 molecule
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN4 claudin 4
COL1A1 collagen, type I, alpha 1
CRH corticotropin releasing hormone
CST6 cystatin E/M
CTSV cathepsin V
CYLD cylindromatosis (turban tumor syndrome)
DDR1 discoidin domain receptor tyrosine kinase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSTN destrin (actin depolymerizing factor)
EDNRB endothelin receptor type B
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR2 early growth response 2
EHD4 EH-domain containing 4
EN1 engrailed homeobox 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FBXO4 F-box protein 4
FGFR3 fibroblast growth factor receptor 3
FLG filaggrin
GADD45A growth arrest and DNA-damage-inducible, alpha
GCM1 glial cells missing homolog 1 (Drosophila)
GDNF glial cell derived neurotrophic factor
GIPC1 GIPC PDZ domain containing family, member 1
GRHL3 grainyhead-like 3 (Drosophila)
HINT1 histidine triad nucleotide binding protein 1
HMGN1 high mobility group nucleosome binding domain 1
HNF1A HNF1 homeobox A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGF2 insulin-like growth factor 2
IL6ST interleukin 6 signal transducer
ING1 inhibitor of growth family, member 1
IP6K2 inositol hexakisphosphate kinase 2
IRF6 interferon regulatory factor 6
JDP2 Jun dimerization protein 2
JUND jun D proto-oncogene
KDF1 keratinocyte differentiation factor 1
KLF10 Kruppel-like factor 10
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT16 keratin 16, type I
KRT7 keratin 7, type II
KRT9 keratin 9, type I
LATS1 large tumor suppressor kinase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKS1 Meckel syndrome, type 1
MTA2 metastasis associated 1 family, member 2
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYH11 myosin, heavy chain 11, smooth muscle
NCOA5 nuclear receptor coactivator 5
NFE2L2 nuclear factor, erythroid 2-like 2
NKX3-1 NK3 homeobox 1
NONO non-POU domain containing, octamer-binding
NR1H4 nuclear receptor subfamily 1, group H, member 4
NTN4 netrin 4
NUPR1 nuclear protein, transcriptional regulator, 1
OPRM1 opioid receptor, mu 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAQR3 progestin and adipoQ receptor family member III
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHF14 PHD finger protein 14
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIP prolactin-induced protein
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKP3 plakophilin 3
PLG plasminogen
PML promyelocytic leukemia
PMP22 peripheral myelin protein 22
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRF protein tyrosine phosphatase, receptor type, F
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RET ret proto-oncogene
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL27A ribosomal protein L27a
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SH2B3 SH2B adaptor protein 3
SHARPIN SHANK-associated RH domain interactor
SKI SKI proto-oncogene
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SPI1 Spi-1 proto-oncogene
SPTAN1 spectrin, alpha, non-erythrocytic 1
SULF1 sulfatase 1
SULF2 sulfatase 2
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TCF3 transcription factor 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TRIM24 tripartite motif containing 24
VCL vinculin