increased bleeding time Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding. (Human Phenotype Ontology, HP_0003010)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005606
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Genes

71 gene mutations causing the increased bleeding time phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ANO6 anoctamin 6
AP3B1 adaptor-related protein complex 3, beta 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
C6ORF25 chromosome 6 open reading frame 25
CD151 CD151 molecule (Raph blood group)
CD40LG CD40 ligand
CLIC1 chloride intracellular channel 1
DOCK7 dedicator of cytokinesis 7
DTNBP1 dystrobrevin binding protein 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F10 coagulation factor X
F11 coagulation factor XI
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
F9 coagulation factor IX
FADS2 fatty acid desaturase 2
FERMT3 fermitin family member 3
FGG fibrinogen gamma chain
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP1BB glycoprotein Ib (platelet), beta polypeptide
GSN gelsolin
HPS1 Hermansky-Pudlak syndrome 1
HPS3 Hermansky-Pudlak syndrome 3
HPS4 Hermansky-Pudlak syndrome 4
HPS5 Hermansky-Pudlak syndrome 5
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIAA1715 KIAA1715
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LYST lysosomal trafficking regulator
MFAP2 microfibrillar-associated protein 2
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MPL MPL proto-oncogene, thrombopoietin receptor
MYH9 myosin, heavy chain 9, non-muscle
NBEAL2 neurobeachin-like 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
RAB27A RAB27A, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RANBP10 RAN binding protein 10
RAP1B RAP1B, member of RAS oncogene family
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SHH sonic hedgehog
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STIM1 stromal interaction molecule 1
TBXA2R thromboxane A2 receptor
TBXAS1 thromboxane A synthase 1 (platelet)
THBS2 thrombospondin 2
TREML1 triggering receptor expressed on myeloid cells-like 1
TUBB1 tubulin, beta 1 class VI
TXNIP thioredoxin interacting protein
TYRP1 tyrosinase-related protein 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VWF von Willebrand factor
WDR1 WD repeat domain 1